Determined to ensure Superman's ultimate sacrifice was not in vain, Bruce Wayne aligns forces with Diana Prince with plans to recruit a team of metahumans to protect the world from an approaching threat of catastrophic proportions.

England has been overrun by a pandemic with no apparent cure. As the infection continues to spread, safety - for a lucky few - looms in the form of a damaged 747 set to seek solace abroad. It's only once the plane is airborne that the survivors discover the infection made it onto the flight with them.